I'm a well read grad student who's bluntly honest about all things, although I try to be most honest about myself.
Spider-Gwen vs Frank Castle?
Awesome. Add in the wrench that Gwen no longer has powers, and this somehow makes it more awesome. Frank Castle is the same powerhouse - for a non superpowered human - in this alternative universe, and Gwen is reliant on her powers. She's been huffing and puffing - and complaining about stairs - all throughout this issue, the first that she's been depowered.
I'm not sure how she plans on fighting Castle, but she does have the possibility of temporary spider-powers. (They can be artificially given to her, but each burst will run out quickly and she's only got a limited supply. So...)
I'm not sure she plans on using her powers against Castle, although it's heavily implied she will. She managed to take him by surprise without her powers, and while he might be obsessed, and care little for criminals, he's also not the kind of evil that actively goes after innocent people - or harms them with no concern for their well being. I kind of like seeing her cope without her powers, though, if only because it's nice to see that she can get by without them. Not as well as with them, but she can scrape by on her own.
And then there's this:

Can we turn poopybritches into a thing? Because I snorted out loud when I saw that phrase.