I'm a well read grad student who's bluntly honest about all things, although I try to be most honest about myself.
I was not into it when I realized that the nanites were out of his system, which is not so much a spoiler as you find out in the first page or two.
I was like, well, there goes all my interest! But the truth is that Ray Garrison, as he's calling himself, feels somewhat lost without Bloodshot. At the same time, he has nightly terrors about what he's done, and what happens if Bloodshot comes back. He'd been turned into a machine only good for killing and then was trying to make right on all his past sins. Who was Bloodshot? Who is Ray Garrison? Where does one end and the other begin?
And should he open that file that tells him who he was before Bloodshot?
There's a lot of meat here for a superhero comic that is extremely light on the action. It's a slow burn of a character study of a man who doesn't know who he is, can't really come to terms with who he is used to be, and has to drink away the fear of who he'll become before he sleeps each night.
It's damn good. I may just pick up the next couple of issues on Comixology.
I don't think you need to read anything previous to this. I've read some Bloodshot, but I don't think that impacted this greatly: everything you need to know about his origins are here, and I didn't read about a lot of the big events that have the most impact on this series, and it was explained well enough that I didn't feel lost.
I do miss nanite enhanced Bloodshot, though!