I'm a well read grad student who's bluntly honest about all things, although I try to be most honest about myself.
Venom Vs. Spider-Man? Well, both Spider-Man and Venom have come a long, long way since their original meeting, but this just as delicious. Otto doesn't know who Flash Thompson - a longtime Spider-Man character, a bully turned hero in the war - and Venom doesn't know that Otto has taken over as Peter Parker/Spider-Man.
The end result? Chaos, really enjoyable chaos. Smartly written, gorgeously illustrated, but this isn't the place to jump into this series. Too much has gone on, and I don't think this will have the same impact if you haven't read the previous volumes.
Plus, they're far too fun to miss if you enjoy your Freaky Friday shenanigans.