I'm a well read grad student who's bluntly honest about all things, although I try to be most honest about myself.
Deadpool is chasing a guy who happens to be a shapeshifter. When he changes into a cheerleader, and Deadpool goes after him? Another big, burly dude tries to save the cheerleader. When Deadpool tries to explain that the 'cheerleader is actually a dude' this happens:
This is just fantastic. And, quite frankly, unexpected: the issues of transgendered people don't often make it into comics, and the writers saw a chance and took it. I was just about to not read more Deadpool after this volume. This one panel has me rethinking this!