I'm a well read grad student who's bluntly honest about all things, although I try to be most honest about myself.
Because using bipolar as a means to give people superpowers - or insanity in general - seems to fetishize this quite a bit, and I'm not a fan of that. It's the way they did it - pills keep the superpowers/insanity down, while getting manic means superpowers. So if the MC - bipolar, and a drug addict - got high, he got manic, and he got stronger. The more manic he got, the more powerful he got, and that just fed into the fetishization of bipolar. There are other ways that this is ablest, too, and again, not a huge fan.
Maybe if I liked the story enough, that wouldn't bother me as much as it did, but the truth is I wasn't crazy about either the story or art. I didn't hate it, though, and there were some interesting concepts, but not enough for me to adore it.